Chinese Journal of Organic Chemistry >
Chemoselectively Synthesis of Resveratrol Oligomers
Received date: 2013-08-19
Revised date: 2013-09-27
Online published: 2013-09-30
Supported by
Project supported by the National Natural Science Foundation of China (No. 21062010), the "Qing Lan" Talent Engineering Funds of Lanzhou Jiaotong University (No. QL-08-06A).
Resveratrol oligomers are a class of plant polyphenols which are formed in nature by oxidative oligomerization of resveratrol catalyzed by enzymes and have received considerable attention of synthetic chemists on account of their structural complexity and diverse biological activities. The biomimetic synthetic strategy based on the oxidative coupling reaction has been extensively studied over the past thirty years, but the lacks of regio-or stereo-selectivity impose restrictions on its universal application. Recently, The synthetic efforts on the diverse skeletons of these oligomers through novel and effective cascade reactions has been a hot research topic and have achieved dramatic success. And they were mostly focused on the synthesis of racemates and the asymmetric synthesis research on these oligomers has just started. In this paper, the progress in the chemical syntheses of resveratrol oligomers in recent seven years is reviewed in detail and the future synthetic trend of oligostilbenes is also prospected.
Key words： resveratrol; oligomerization; chemoselectivity; total synthesis
Li Wenling, Lü Teng, Yang Yuhua, Yang Yadong . Chemoselectively Synthesis of Resveratrol Oligomers[J]. Chinese Journal of Organic Chemistry, 2013 , 33(12) : 2443 -2459 . DOI: 10.6023/cjoc201308023
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