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Chinese Journal of Organic Chemistry >

2014 , Vol. 34 >Issue 2: 429 - 433

DOI: https://doi.org/10.6023/cjoc201307023

Notes

Synthesis of Novel 5,6-2H-Lamellarin η and Analogues

  • Wang Ailing ,
  • Zheng Xueliang ,
  • Zhao Zhuangzhi ,
  • Li Changping ,
  • Tao Bo ,
  • Zheng Xuefanng
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  • a College of Environment and Chemical Engineering, Dalian University, Dalian 116622;
    b Liaoning Key Laboratory of Bio-organic Chemistry, Dalian University, Dalian 116622;
    c College of Agronomy, Northeast Agricultural University, Harbin 150030

Received date: 2013-07-16

  Revised date: 2013-09-18

  Online published: 2013-10-10

Supported by

Project supported by the National Natural Science Foundation of China (No. 21271036) and the Outstanding Young Talent Fund from the Dalian Science and Technology Bureau (No. 2009J22DW038).

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Abstract

According to the reaction of "Knorr condensation-esterification-cyclization", the target compounds, 6-2H- lamellarin η (5a) and analogues 5b were synthesized successfully from 2,4-diisopropoxy-α-bromo-acetophenone compounds 1a, 1b and the isoquinoline compound 1c. Two kinds of novel open-chain lamellarins (compounds Ⅰ, Ⅱ) were accompanied to obtain during the synthesis of 5a. In this paper, ten compounds had been got including six new compounds, which are identified by 1H NMR, 13C NMR, MS, IR, HRMS techniques.

Key words： 5,6-2H-lamellarin η; synthesis; Knorr condensation

Cite this article

Wang Ailing , Zheng Xueliang , Zhao Zhuangzhi , Li Changping , Tao Bo , Zheng Xuefanng . Synthesis of Novel 5,6-2H-Lamellarin η and Analogues[J]. Chinese Journal of Organic Chemistry, 2014 , 34(2) : 429 -433 . DOI: 10.6023/cjoc201307023

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