Chinese Journal of Organic Chemistry >
Research Progress of Apratoxin A：A Marine Cyclicdepsipeptide with Significant Anti-cancer Activity
Received date: 2013-10-21
Revised date: 2013-12-04
Online published: 2013-12-06
Supported by
Project supported by the National Natural Science Foundation of China (No. 81001392, 81172975), the Project to Enhance the Research Ability of Young Teachers (Fudan University), and the National High Technology Research and Development Program of China (863 Program, No. 2013AA092903).
Apratoxin A, a marine natural cyclicdepsipeptide bearing novel and complex structure, showed significant antiproliferative activity against several cancer cell lines. A brief introduction on the research progress of this natural product including total synthesis, structure-activity relationship, pharmacological studies, and biosynthetic pathway was summarized.
Key words： apratoxin A; marine bioactive peptide; anti-cancer
Zhang Wei , Liu Guoyun , Yin Ruwen , Li Yingxia . Research Progress of Apratoxin A：A Marine Cyclicdepsipeptide with Significant Anti-cancer Activity[J]. Chinese Journal of Organic Chemistry, 2014 , 34(3) : 475 -484 . DOI: 10.6023/cjoc201310033
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