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Chinese Journal of Organic Chemistry >

2014 , Vol. 34 >Issue 4: 829 - 834

DOI: https://doi.org/10.6023/cjoc201311027

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Synthesis and Antibacterial Activities of Novel Phosphonate Derivatives Containing Quinolinone Moiety

  • Yang Jiaqiang ,
  • Hu Yuewei ,
  • Gu Qing ,
  • Li Minggang ,
  • Li Mingqiang ,
  • Song Baoan
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  • a School of Pharmacy, Zunyi Medical College, Zunyi 563003;
    b Laboratory of Microbiology and Immunology, Zunyi Medical College, Zunyi 563003;
    c Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025

Received date: 2013-11-15

  Revised date: 2013-12-11

  Online published: 2013-12-23

Supported by

Project supported by the Technology Department of Guizhou Province (No. LKZ[2010]47).

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Abstract

According to substructure link principle, a series of novel phosphonate derivatives bearing quinolinone moiety were designed and synthesized. The structures of the products were confirmed by IR, 1H NMR and MS data. The antibacterial activities of the products against S. aureus, E.coli, drug-resistant S. aureus were evaluated by the agar dilution method. The results demonstrated that some compound exhibited superior activities against drug-resistant S. aureus compared with norfloxacin. Especially, compound Ⅲk showed more potent activities against MRSA15# with minimum inhibitory concentration (MIC) values of 6.2 mg/mL, and against QRSA7# with MIC values of 3.1 mg/mL.

Key words： quinolinone; α-aminophosphonate; amide; synthesis; antibacterial activity

Cite this article

Yang Jiaqiang , Hu Yuewei , Gu Qing , Li Minggang , Li Mingqiang , Song Baoan . Synthesis and Antibacterial Activities of Novel Phosphonate Derivatives Containing Quinolinone Moiety[J]. Chinese Journal of Organic Chemistry, 2014 , 34(4) : 829 -834 . DOI: 10.6023/cjoc201311027

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