Chinese Journal of Organic Chemistry >
Synthesis and Anti-hepatitis B Virus Activities of Nitric Oxide-Releasing Derivatives of Matijin-Su
Received date: 2013-12-02
Revised date: 2014-01-03
Online published: 2014-01-03
Supported by
Project supported by the National Natural Science Foundation of China (No. 81360472), and the Graduate Education Innovation Project of Guiyang College of Traditional Chinese Medicine (No. ZYYCX12018).
By using N-(N-benzoyl-L-phenylalanyl)-O-acetyl-L-phenylalanol, named Matijin-Su, as a lead compound, a series of nitric oxide-releasing derivatives of Matijin-Su were synthesized and evaluated for their anti-hepatitis B virus activities in HepG2 2.2.15 cells. Compounds 6d, 6e and 6g exhibited significant anti-HBV activities. The 50% inhibitory concentrations of these compounds towards HepG2 2.2.15 cells were 6.88, 37.51 and 11.07 μmol/L. Compounds 6d and 6g were less than Matijin-Su (IC50: 11.16 μmol/L). Compound 6d has potent in vitro anti-HBV activity, and could be worth of further research.
Liang Guangping , Cao Peixue , Yang Xiuxia , Huang Zhengming , Liu Qingchuan , Liang Guangyi , Xu Bixue . Synthesis and Anti-hepatitis B Virus Activities of Nitric Oxide-Releasing Derivatives of Matijin-Su[J]. Chinese Journal of Organic Chemistry, 2014 , 34(5) : 973 -979 . DOI: 10.6023/cjoc201312003
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