Chinese Journal of Organic Chemistry >
Synthesis of cis-1, 2-Dihalosubstituted 1, 7-Octadienes by Pd-Catalyzed Cross-Coupling Reaction in Ionic Liquids
Received date: 2014-01-10
Revised date: 2014-02-24
Online published: 2014-03-03
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21102047, 31101221) and the South China University of Technology Student Research Project.
A Pd-catalyzed method was developed for cross-coupling reaction of a wide range of haloalkynes with hex-5-en-1-ol in ionic liquids. In the presence of PdBr2, [Bmim]X and HXaq, the cross-coupling products can be obtained in moderate to good yields, and the reaction displayed high regio- and stereo-selectivities. Moreover, the reaction is a convenient and simple path for the synthesis of the cis-1,2-dihalosubstituted alkenes, and tolerates several functional groups on haloalkynes.
Yang Shaorong , Ling Changwei , Ma Jianye , Zhang Lei , Li Jianxiao , Luo Wei . Synthesis of cis-1, 2-Dihalosubstituted 1, 7-Octadienes by Pd-Catalyzed Cross-Coupling Reaction in Ionic Liquids[J]. Chinese Journal of Organic Chemistry, 2014 , 34(6) : 1148 -1153 . DOI: 10.6023/cjoc201401017
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