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Chinese Journal of Organic Chemistry >

2014 , Vol. 34 >Issue 5: 886 - 892

DOI: https://doi.org/10.6023/cjoc201402006

ARTICLE

Preparation of Active Resveratrol Dimeric Derivatives by Oxidative Coupling Reaction Using AgOAc as Oxidant

  • Zhang Yuan ,
  • Wang Xianfen ,
  • Hou Qi ,
  • Lin Mingbao ,
  • Yao Chunsuo ,
  • Shi Jiangong
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  • a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050;
    b College of Chemistry & Material Science, Hebei Normal University, Shijiazhuang 050024

Received date: 2014-02-05

  Revised date: 2014-03-19

  Online published: 2014-04-01

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Abstract

Oxidative coupling reaction of resveratrol in methanol using silver acetate as oxidant gave seven resveratrol dimeric derivatives 1～7. Their structures and relative configurations were determined on the basis of spectral analysis, and their formation mechanisms were discussed, respectively. Among them, compounds 3, 4 and 5 were determined as new stilbene dimers, and compounds 6 and 7 were synthesized as natural compounds for the first time. All the compounds were evaluated for anti-inflammatory activities.

Key words： silver acetate; oxidative coupling reaction; resveratrol dimeric derivatives; anti-inflammatory acivities

Cite this article

Zhang Yuan , Wang Xianfen , Hou Qi , Lin Mingbao , Yao Chunsuo , Shi Jiangong . Preparation of Active Resveratrol Dimeric Derivatives by Oxidative Coupling Reaction Using AgOAc as Oxidant[J]. Chinese Journal of Organic Chemistry, 2014 , 34(5) : 886 -892 . DOI: 10.6023/cjoc201402006

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(卜鹏滨, 里艳茹, 姜明, 王晓良, 王芳, 林生, 朱承根, 石建功, 中国中药杂志, 2013, 38, 13.)

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