Chinese Journal of Organic Chemistry >
Synthesis and Fungicidal Activity of D-Ribose and D-Xylose with Hydantion
Received date: 2014-01-21
Revised date: 2014-03-05
Online published: 2014-04-15
Supported by
Project supported by the National Key Technologies R&D Program (No. 2011BAE06B03).
The α-D-ribose and α-D-xylose C(5)-aldehyde derivatives (1 and 2) were prepared through four and two steps using 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose as raw material. Then 1 and 2 reacted with hydantoin phosphonate and 2-thiohydantoin by Wittig-Horner and Knoevenagel reaction to afford 3 pairs of E and Z isomers of target products 3～5. Their structures were elucidated by 1H NMR, 13C NMR, IR, MS and X-ray diffraction. The preliminary bioassay results showed that some of them have certain fungicidal activities against 7 plant pathogens at the concentration of 50 μg/mL.
Key words： hydantoin; ribose; xylose; fungicidal activity
Liu Bin , Han Jintao , Tang Bo , Wang Mingan . Synthesis and Fungicidal Activity of D-Ribose and D-Xylose with Hydantion[J]. Chinese Journal of Organic Chemistry, 2014 , 34(7) : 1442 -1446 . DOI: 10.6023/cjoc201401035
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