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Chinese Journal of Organic Chemistry >

2014 , Vol. 34 >Issue 8: 1677 - 1681

DOI: https://doi.org/10.6023/cjoc201403017

Notes

Biphenyl Lignans with a Tetrahydrofuran Moiety from Gymnotheca chinensis Decne

  • Xiao Shiji ,
  • Fang Dongmei ,
  • Xia Bing ,
  • Xu Linfeng ,
  • Xu Hongxi ,
  • Jiang Yan ,
  • Chen Fang ,
  • Ding Lisheng ,
  • Zhou Yan
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  • a Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041;
    b College of Life Science, Sichuan University, Chengdu 610064;
    c Shanghai University of Traditional Chinese Medicine, Shanghai 201203

Received date: 2014-03-07

  Revised date: 2014-04-07

  Online published: 2014-04-18

Supported by

Project supported by the National Natural Sciences Foundation of China (Nos. 30973634, 21302180).

Fold

Abstract

Four new biphenyl lignans with a tetrahydrofuran moiety, named gymnothelignans X1, X2, Y1, and Y2 (1～4), were isolated from the methanol extract of the whole plants of Gymnotheca chinensis Decne. The chemical structures were established by means of spectroscopic analysis including 1D and 2D NMR spectroscopy and HR-ESIMS. Compound 1 exhibited moderate cytotoxicity against the HCT116, HCT15, A549, MCF-7 and HepG2 cancer cell lines with IC50 values of 18.4, 11.2, 26.5, 9.1 and 23.5 μmol·L-1, respectively.

Key words： saururaceae; Gymnotheca chinensis; atropisomer; biphenyl lignan; gymnothelignan

Cite this article

Xiao Shiji , Fang Dongmei , Xia Bing , Xu Linfeng , Xu Hongxi , Jiang Yan , Chen Fang , Ding Lisheng , Zhou Yan . Biphenyl Lignans with a Tetrahydrofuran Moiety from Gymnotheca chinensis Decne[J]. Chinese Journal of Organic Chemistry, 2014 , 34(8) : 1677 -1681 . DOI: 10.6023/cjoc201403017

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