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Chinese Journal of Organic Chemistry >

2014 , Vol. 34 >Issue 8: 1673 - 1676

DOI: https://doi.org/10.6023/cjoc201403016

Notes

Synthesis of Multi-substituted 1,4-Dihydropyridine Derivatives from Acetoacetanilides

  • Chen Cui ,
  • Tan Liquan ,
  • Qiu Huihua
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  • College of Chemcal Engineering, Guangdong University of Petrochemical Technology, Maoming 525000

Received date: 2014-03-07

  Revised date: 2014-04-02

  Online published: 2014-04-18

Supported by

Project supported by the Natural Science Foundation of Guangdong Province (No. S2012040007868).

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Abstract

This paper reports a simple intermolecular condensation reaction for the synthesis of 1,4-dihydropyridine derivatives from acetoacetanilides using AcOH as the solvent and ammonium persulfate[(NH4)2S2O4] as the oxidant. The structures of products were confirmed by IR, 1H NMR, 13C NMR and HR-MS. In addition, a possible reaction mechanism was proposed.

Key words： ammonium persulfate; intermolecular condensation; 1,4-dihydropyridine derivatives; acetoacetanilides

Cite this article

Chen Cui , Tan Liquan , Qiu Huihua . Synthesis of Multi-substituted 1,4-Dihydropyridine Derivatives from Acetoacetanilides[J]. Chinese Journal of Organic Chemistry, 2014 , 34(8) : 1673 -1676 . DOI: 10.6023/cjoc201403016

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