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Chinese Journal of Organic Chemistry >

2014 , Vol. 34 >Issue 8: 1662 - 1668

DOI: https://doi.org/10.6023/cjoc201402035

Notes

Synthesis and Biological Activity of Oxime Ethers of Curcumin Derivatives

  • Chen Yu ,
  • Wang Zhongbo ,
  • Zhang Xian ,
  • Xia Lijuan ,
  • Gong Huayu ,
  • Zhao Hongju ,
  • Xue Wei
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  • State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Bioengineering of Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025

Received date: 2014-02-27

  Revised date: 2014-04-30

  Online published: 2014-05-05

Supported by

Project supported by the National Tweifth Five-Year Plan for Science and Technology (No. 2011BAE06B04-09) and the Innovation Fund for Graduate Student of Guizhou University (No. 2013036)

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Abstract

On the principle of biologically active factor splicing, curcumin derivatives introduced active functional group oxime ethers into the structure of 1,4-pentadien-3-one. A series of new 1-phenyl-5-heterocycle-1,4-pentadien-3-one oxime ethers were synthesized, and their structures were identified by IR, 1H NMR, 13C NMR, ESI-MS and elemental analysis. The preliminary bioassay results indicated that target compounds showed certain antiviral activity against TMV at a concentration of 500 μg/mL.

Key words： curcumin; oxime ether; synthesis; anti-TMV activity

Cite this article

Chen Yu , Wang Zhongbo , Zhang Xian , Xia Lijuan , Gong Huayu , Zhao Hongju , Xue Wei . Synthesis and Biological Activity of Oxime Ethers of Curcumin Derivatives[J]. Chinese Journal of Organic Chemistry, 2014 , 34(8) : 1662 -1668 . DOI: 10.6023/cjoc201402035

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