Chinese Journal of Organic Chemistry >
Progresses in Synthesis of Vernakalant
Received date: 2014-03-18
Revised date: 2014-04-10
Online published: 2014-05-05
Supported by
Project supported by the Program of Marine Biological Resources Exploitation and Utilization of Science and Technology Innovation Team of Taizhou (No. MBR2014004), and the Innovation Research Foundation of Graduate School of Zhejiang Province (No. YK2011030).
The traditional antiarrhythmic drug is very efficient, but with arrhythmogenic, organ toxicity and other side effects. Vernakalant is a new antiarrhythmic drug of mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blockers. Recent clinical studies show that vernakalant under development for the acute conversion of atrial fibrillation to sinus rhythm is better than amiodarone, so it can be expected to have a good prospect for clinical application. In this review, representative synthetic routes employing chemical or biological resolution and catalytic asymmetric reactions are briefly summarized.
Key words： vernakalant; synthesis; progress
Ye Haiwei , Chen Yunhua , Zhou Liping , Yu Chuanming . Progresses in Synthesis of Vernakalant[J]. Chinese Journal of Organic Chemistry, 2014 , 34(9) : 1759 -1765 . DOI: 10.6023/cjoc201403041
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