Chinese Journal of Organic Chemistry >
Synthesis and Fungicidal Activity of New Pyrrolpyrazole Compounds
Received date: 2014-04-03
Revised date: 2014-05-07
Online published: 2014-06-09
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21371052 and 21272061) and the Scientific Research Fund of Heilongjiang Provincial Education Department (No. 12531512).
With the aim of obtaining new potential fungicide candidates with higher biological activities and environmental safety, ten new pyrrolpyrazole compounds based on the structures of fludioxonil were designed and synthesized. The benzene ring in original fludioxonil structure is replaced by pyrazole ring to improve its bactericidal activity. All the structures of target products and their intermediates are characterized and confirmed by 1H NMR, FTIR, single crystal diffraction, HPLC, elemental analysis and melting point determination. Six single crystals of final products are also achieved by volatilization under room temperature. Biological activity tests are conducted for six compounds. The results show that each compound exhibits certain antibacterial activity toward rhizoctonia, botrytis cinerea and cucumber downy mildew, which provides valuable information for further development of new pesticides fungicides.
Wang Zishi , Ye Hantao , Xiao Dan , Ma Dongsheng , Gao Jinsheng , Yu Yinghui , Hou Guangfeng , Yan Pengfei . Synthesis and Fungicidal Activity of New Pyrrolpyrazole Compounds[J]. Chinese Journal of Organic Chemistry, 2014 , 34(10) : 2057 -2062 . DOI: 10.6023/cjoc201404008
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