Chinese Journal of Organic Chemistry >
Design, Synthesis and Bioactivities of Novel N-Methyl-carbamoylphenyl Nicotinoyl Ureas
Received date: 2014-04-22
Revised date: 2014-05-16
Online published: 2014-06-11
In order to look for new pesticidal leading compounds, 12 novel nicotinoyl ureas were designed and synthesized based on the structure fragments of chlorantraniliprole and 2-chloronicotinic acid according to the bio-rational design principle. The structures of all compounds have been confirmed by 1H NMR, 13C NMR, IR and HRMS techniques. The preliminary results of biological sceen indicated that some of the title compounds exhibited high insecticidal activities against Mythimna separate. At 500 mg/L, compounds 5a, 5g and 5h exhibited a insecticidal activity of 100%. In additional, some compounds showed herbicidal activities, such as 100 mg/L of compounds 5f inhibited 80% root growth against Echinochloa crusgalli.
Liu Jianhua , Li Yiming , Mao Dajie , Du Xiaohua . Design, Synthesis and Bioactivities of Novel N-Methyl-carbamoylphenyl Nicotinoyl Ureas[J]. Chinese Journal of Organic Chemistry, 2014 , 34(10) : 2140 -2145 . DOI: 10.6023/cjoc201404040
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