Chinese Journal of Organic Chemistry >
Studies of Molecular Structures of 3,17-Androstandiol Derivative
Received date: 2014-04-17
Revised date: 2014-06-01
Online published: 2014-06-18
Supported by
Project supported by the National Natural Science Foundation of China (No. 31200451), the Natural Science Foundation of Jiangsu Province (No. BK2012821) and the Foundation of Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions.
Rocuronium bromide is a new neuromuscular blocking agent in clinical intervention. Its potency, specificity of action and little side effect have been confirmed. The 3,17-androstandiol (1) is a key intermediate for the preparation of rocuronium bromide. In this paper, The 3,17-androstandiol (1) was synthesized from (2α,3α,5α,16β)-2,3-epoxy-16- (1-pyrrolidinyl)-17-oxoandrostane by a reduction with sodium borohydride in methanol and then an epoxy ring opening reaction in morpholine and water. The molecular constitution was confirmed by 1H NMR, 13C NMR, 1H-1H COSY, DEPT, HSQC,HMBC, 2D NOESY and TOF-MS spectra. The single crystal of 3,17-androstandiol (1) was prepared by crystallized from 2-MeTHF and then was subjected to X-ray crystallography analysis that confirmed the stereo configuration of compound 1. And studies of X-ray powder diffractive analysis indicate that the diffractive spectrum of the sample compound 1 is consistent with the diffractive spectrum calculated on the crystal data. Therefore, the compound is (2β,3α,5α,16β,17β)- 2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstan-3,17-diol and its stereochemistry is accordant with that of rocuronium bromide.
Key words: androstandiol; rocuronium bromide; NMR spectra; configuration; crystal structure
Fang Mingfeng , Chu Gang , Li Xin , Lu Guo Yuan . Studies of Molecular Structures of 3,17-Androstandiol Derivative[J]. Chinese Journal of Organic Chemistry, 2014 , 34(10) : 2119 -2123 . DOI: 10.6023/cjoc201404031
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