Chinese Journal of Organic Chemistry >
Synthesis and Antitumor Activity Evaluation of Novel Tetrahydro-[4,5]benzothieno[2,3-d]pyrimidinone Derivatives
Received date: 2014-05-12
Revised date: 2014-06-17
Online published: 2014-07-03
Supported by
Project supported by the Special Fund for Basic Scientific Research of Central Colleges, South-Central University for Nationalities (No.CZY13004).
Six 3-alkyl-5,6,7,8-tetrahydro[4,5]benzothieno[2,3-d]pyrimidin-4-one derivatives and seventeen 3-benzylidene- aminotetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-one derivatives have been designed and synthesized via Gewald reaction under mild condition. The structures of synthesized compounds were characterized by 1H NMR, 13C NMR, IR and MS. Their antitumor activities were evaluated against human nasopharyngeal carcinoma (KB) and human nasopharyngeal carcinoma (CNE2) cell lines in vitro. These results revealed that four tested compounds showed moderate antitumor activities.
Chen Yu , Bai Shun , He Hongwu , Yang Guangzhong . Synthesis and Antitumor Activity Evaluation of Novel Tetrahydro-[4,5]benzothieno[2,3-d]pyrimidinone Derivatives[J]. Chinese Journal of Organic Chemistry, 2014 , 34(11) : 2362 -2369 . DOI: 10.6023/cjoc201405018
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