Chinese Journal of Organic Chemistry >
Synthesis and Antibacterial Activities of Mannich Bases of Curcumin Derivatives
Received date: 2014-05-16
Revised date: 2014-06-22
Online published: 2014-07-15
Supported by
Project supported by the Key Foundation of Science and Technology Bureau of Leshan City in Sichuan Province (No.08SZD092), the Application of Basic Project of Science and Technology Agency of Sichuan Province (No.2010JY0148), and the Project of Leshan Normal University (No.Z1321).
In order to find new lead compounds for the design of new antibacterial drugs, eight novel Mannich bases of the curcumin were synthesized for the first time by Mannich reaction of curcumin, formaldehyde and various secondary amines. All the new synthesized curcumin Mannich base compounds were characterized by 1H NMR, 13C NMR, IR, MS and elemental analysis. These curcumin Mannich bases were tested in vitro against different germ and mildew, and all of them have shown better activities than curcumin against B. subtilis, S. aureus, E. coli, A. niger, and Penicillium ch. The results showed that the curcumin Mannich bases containing piperazine ring have obvious mildew resistance (with inhibition zone of up 16.88 mm to 21.34 mm).
Key words： curcumin; Mannich reaction; Mannich base; synthesis; antimicrobial activity
Liu Zhichang , Wang Yinghong , Zeng Hongyao , Nie Wanli , Xiang Qingxiang . Synthesis and Antibacterial Activities of Mannich Bases of Curcumin Derivatives[J]. Chinese Journal of Organic Chemistry, 2014 , 34(11) : 2345 -2349 . DOI: 10.6023/cjoc201405024
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