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Chinese Journal of Organic Chemistry >

2014 , Vol. 34 >Issue 12: 2543 - 2550

DOI: https://doi.org/10.6023/cjoc201405007

ARTICLE

Study of Synthesis and Biological Activities of a Novel Macrolide Derivatives

  • Shi Daxin ,
  • Feng Xue ,
  • Zhuang Xiaolei ,
  • Chai Hongxin ,
  • Liu Ting ,
  • Zhang Qi ,
  • Li Jiarong
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  • a. School of Chemical Engineering and Environment, Beijing institute of Technology, Beijing 100081;
    b. Beijing Academy of Agricultural and Forestry Sciences, Beijing 100097

Received date: 2014-05-06

  Revised date: 2014-07-28

  Online published: 2014-08-11

Supported by

Project supported by the Basic Research Fund of Beijing Institute of Technology (No. 20131042006).

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Abstract

Modification of molecular structure of pesticides is a common method to seek new efficient broad-spectrum insecticides. This study focused on modifying the structure of deglycosylated or partially deglycosylated spinosad. Eight new macrolide derivatives had been synthesized by acylation. Their structures were characterized by 1H NMR, 13C NMR and MS techniques. Their fungicidal and insecticidal activities were also evaluated. The results showed that all compounds synthesized had excellent insecticidal activities against lepidoptera, coleoptera, diptera, hemiptera and nematoda. Compound 3e at the concentration of 100 mg/L presented 100% insecticidal activity against hemiptera (e.g. Myzus persicae) and compounds 3f and 3h loading 200 μg presented certain inhibition against pseudomonas.

Key words： macrolide; acylate; insecticidal activity; fungicidal activity

Cite this article

Shi Daxin , Feng Xue , Zhuang Xiaolei , Chai Hongxin , Liu Ting , Zhang Qi , Li Jiarong . Study of Synthesis and Biological Activities of a Novel Macrolide Derivatives[J]. Chinese Journal of Organic Chemistry, 2014 , 34(12) : 2543 -2550 . DOI: 10.6023/cjoc201405007

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