Chinese Journal of Organic Chemistry >
One-Pot Three-Component Synthesis of New β-Indole Derivatives in Gluconic Acid Aqueous Solution
Received date: 2014-06-18
Revised date: 2014-07-09
Online published: 2014-08-29
Supported by
Project supported by the National Science and Technology Support Program of China (No. 2009BAI75B02), the Innovation Fund Designated for Graduate Students of Jiangxi Province (No. YC2014), and the Outstanding Doctoral Dissertation Cultivation Program of Jiangxi Normal University.
One-pot three-component reactions of aldehydes with indole and 2,2-pentamethylene-1,3-dioxane-4,6-dione afforded thirteen kinds of 5-[(indol-3-yl)-methyl]-2,2-pentamethylene-1,3-dioxane-4,6-dione derivatives (β-indole derivatives) in the presence of gluconic acid aqueous solution in 66.4%～98.5% yields. The advantages of this protocol were mild reaction conditions, wide substrate scope, high yields and benign to environment, which afforded an effective method to synthesize β-indole derivatives.
Yan Nan , Xia Jianhui , Xiong Yunkui , Xiong Bin , Lin Chunhua , Liao Weilin . One-Pot Three-Component Synthesis of New β-Indole Derivatives in Gluconic Acid Aqueous Solution[J]. Chinese Journal of Organic Chemistry, 2014 , 34(12) : 2487 -2492 . DOI: 10.6023/cjoc201406010
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