Chinese Journal of Organic Chemistry >
First Total Synthesis of (±)-Cycloaltilisin 7 and (±)-Poinsettifolin B
Received date: 2014-07-31
Revised date: 2014-09-07
Online published: 2014-09-18
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21362025, 21162021) and the Program for New Century Excellent Talents in University (No. NCET-09-0860).
Cycloaltilisin 7, isolated from the bud covers of Artocarpus altilis, is a new isoprenyl flavone and has the potential cathepsin K inhibitory activity; while poinsettifolin B is another new geranyl chalcone isolated from the extract of Dorsetenia poinsettifolia, an native cameroonian herb used for the treatment of yaws disease, infection, and other possible skin diseases. Starting from the inexpensive hydroxyl acetophenones and hydroxyl benzaldehydes, the first total syntheses of these two natural products are accomplished with simple and mild conditions. The structures of all new compounds are elucidated by HRMS, 1H NMR and 13C NMR spectra.
Key words： cycloaltilisin 7; poinsettifolin B; flavanoid; chalcone; total synthesis
Ma Xiaoqin , Yang Jinhui , Feng Yao , Chen Bingbing , Xie Yimin . First Total Synthesis of (±)-Cycloaltilisin 7 and (±)-Poinsettifolin B[J]. Chinese Journal of Organic Chemistry, 2014 , 34(10) : 2001 -2006 . DOI: 10.6023/cjoc201407047
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