Chinese Journal of Organic Chemistry >
A Facile Synthesis of Thiazole Skeleton-Containing Indole Derivatives
Received date: 2014-07-10
Revised date: 2014-09-03
Online published: 2014-09-25
Supported by
Project supported by the National Natural Science Foundation of China (No. 21476028) and the Natural Science Foundation of Liaoning Province (No. 20120201).
An efficient and easy method for the synthesis of thiazole-containing indole derivatives was described, involving the condensation reaction of 5-chloroacetyloxindole with thiourea (substituted thiourea) and thioamide in the solvent of absolute ethanol via Hantzseh reaction to give the corresponding 5-(2-substituted-thiazol-4-yl)indolin-2-one (2a～2k) and 5-(2-substituted-thiazol-4-yl)indolin-2-one (2l～2q), respectively. The procedure has the advantages of simple operation, mild reaction conditions, and good yields. All of compounds were new and their structures were confirmed by IR, MS, P1PH NMR and P13PC NMR spectra and elemental analyses.
Gao Wentao , Lan Shuai , Zheng Hongmei , Bairenqing Zhuoma . A Facile Synthesis of Thiazole Skeleton-Containing Indole Derivatives[J]. Chinese Journal of Organic Chemistry, 2015 , 35(1) : 144 -151 . DOI: 10.6023/cjoc201407014
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