Chinese Journal of Organic Chemistry >
Dimerization Coupling Reaction of Terminal Alkyne Promoted by CuI/DEAD
Received date: 2014-06-13
Revised date: 2014-09-29
Online published: 2014-10-13
Supported by
Project supported by the Zhejiang Provincial Natural Science Foundation of China (No. LY12B02017).
The dimerization coupling reaction of terminal alkynes is an important method for the synthesis of conjugated carbon-carbon triple bond compounds. Catalyzed by CuI and assisted by diethyl azodicarboxylate, a variety of aromatic and aliphatic alkynes could be dimerized to give the Glaser coupling products using a catalytic amount of N-methylimidazole as a base. The effect of copper catalysts and solvents on this reaction was surveyed. It has the advantage of high yields, simple operation, and mild reaction condition.
Key words： CuI; diethyl azodicarboxylate; terminal alkyne; Glaser reaction
Yang Zhenping , Wang Bingnan , Xu Xiaoliang , Wang Hong , Li Xiaonian . Dimerization Coupling Reaction of Terminal Alkyne Promoted by CuI/DEAD[J]. Chinese Journal of Organic Chemistry, 2015 , 35(1) : 207 -211 . DOI: 10.6023/cjoc201406016
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