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Efficient Synthesis of 3,3'-Aryl(alkyl)-bis(4-aminocoumarine) and 1,4-Dihydropyridino[3,2-c][5,6-c]dicoumarines
Received date: 2014-08-26
Revised date: 2014-10-08
Online published: 2014-10-16
Supported by
Project supported by the Science and Technology Department of Liaoning Province (No. 2011220022).
A simple and efficient procedure for the preparation of 3,3'-aryl(alkyl)-bis(4-aminocoumarine)s has been developed by the reaction of 4-hydroxycoumarin and aldehydes in MeOH under room temperature conditions in the presences of KHSO4 as a catalyst. 1,4-Dihydropyridino[3,2-c][5,6-c]dicoumarines were also obtained via condensation of 4-hydroxycou- marin and aldehydes in HOAc under reflux conditions in good yields. All of above compounds have been confirmed by IR, NMR spectra and elemental analysis.
Wang Daolin , Wu Jianying , Dong Zhe , Wu Dan , Wang Yongyang . Efficient Synthesis of 3,3'-Aryl(alkyl)-bis(4-aminocoumarine) and 1,4-Dihydropyridino[3,2-c][5,6-c]dicoumarines[J]. Chinese Journal of Organic Chemistry, 2015 , 35(1) : 200 -206 . DOI: 10.6023/cjoc201408031
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