Chinese Journal of Organic Chemistry >
Direct Amination of N-Acyliminium Ion Surrogates: A Convenient Access to gem-Diamines Derivatives
Received date: 2014-10-11
Revised date: 2014-10-22
Online published: 2014-10-23
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21172162, 21372174) and the Project Funded by the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions.
A novel 4-methylbenzenesulfonic acid (PTSA)-catalyzed intermolecular amination of N-acyliminium species with various N-sources via benzylic C(sp3)-O activation of functionalized 2-oxo-1-pyrrolidine derivatives has been developed. This method provides an efficient and chromatography-free access to gem-diamines equivalent with moderate to good yields. Because of the importance of gem-diamine derivatives, the methodology is expected to have a significant value for practical applications.
Key words： N-acyliminium ion; gem-diamines; green chemistry
Yang Jinming , Chu Xueqiang , Ji Shunjun . Direct Amination of N-Acyliminium Ion Surrogates: A Convenient Access to gem-Diamines Derivatives[J]. Chinese Journal of Organic Chemistry, 2014 , 34(12) : 2462 -2470 . DOI: 10.6023/cjoc201410017
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