Chinese Journal of Organic Chemistry >
Synthesis and Biological Activities of Novel Analogues of Phthalamide Containing Acylurea and Acylthiourea
Received date: 2014-09-05
Revised date: 2014-10-30
Online published: 2014-11-27
Supported by
Project supported by the National Basic Research Program of China (973 Program, No. 2010CB126106), the National Natural Science Foundation of China (Nos. 31370039, 21272129), the National Key Technologies R&D Program (No. 2011BAE06B05), and the Specialized Research Fund for the Doctorial Program of Higher Education (No. 20110031110017).
In order to find novel and efficient insecticides targeting at the ryanodine receptor, a series of novel compounds containing acylurea and acylthiourea, referring to moieties of flubendiamide and diflubenzuron, were designed and synthesized. Their structures were characterized by 1H NMR, HRMS and X-ray diffraction. The insectical activities showed that the introducing of acylurea and acylthiourea bridges decreased the acitivity. Compound 7d showed 50% activity at the concentration of 10 mg/L. In addtion, some structures showed moderate antifungal activities. Compound 8f displayed 75.0%, 87.5% and 84.6% antifungal activities against Botryosphaeria dothidea, Rhizoctonia cerealis and Fusarium fujikuroi.
Chen Youwei , Wan Yingying , Liu Qiaoxia , Liu Jingbo , Xiong Lixia , Yu Shujing , Li Zhengming . Synthesis and Biological Activities of Novel Analogues of Phthalamide Containing Acylurea and Acylthiourea[J]. Chinese Journal of Organic Chemistry, 2015 , 35(4) : 882 -889 . DOI: 10.6023/cjoc201409005
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