Chinese Journal of Organic Chemistry >
Rencent Advances in Cyclin-Dependent Kinase Inhibitors with Purine Scaffold
Received date: 2014-10-29
Revised date: 2014-11-28
Online published: 2014-12-02
Supported by
Project supported by the Education Department of Henan Province Science and Technology Research Projects (No.14A150052), Scientific Research Plan of Zhenzhou (No.121PPTGG509-2).
Cell cycle is a basic characteristic of a cell that associates with its division and duplication. An entire cell cycle is regulated by a series of enzymes. The occurance of cell cycle disorder can lead to an excessive cell proliferation which may trigger cancer. However, the drugs that target cyclin-dependent kinases could spur the process of cancer cell apoptosis through interrupting the cell cycle. In this article, different kinds of cyclin-dependent kinases (CDKs), cyclins, the mechanism of cell cycle regulation and its relation with cancers are reviewed. The CDKs inhibitors with purine scaffold are introduced and their progresses in research and development are briefly discussed.
Key words： cell cycle; cyclin-dependent kinases; inhibitors; anticancer
Zhang Jingyu , Wang Qinglong , Hou Xuehui , Liu Hongmin . Rencent Advances in Cyclin-Dependent Kinase Inhibitors with Purine Scaffold[J]. Chinese Journal of Organic Chemistry, 2015 , 35(5) : 1022 -1032 . DOI: 10.6023/cjoc201410039
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