Chinese Journal of Organic Chemistry >
New Synthesis of Brivudine and Its Analogs
Received date: 2014-10-24
Revised date: 2014-11-22
Online published: 2014-12-09
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21172057, 21272058, 21202040), and the Research Fund for the Doctoral Program of Higher Education (No. 20114104110005).
In this paper, a simple and practical method for the preparation of brivudine (BVDU) and its analog nucleoside derivatives via condensation of the easily obtainable 5-formyl pyrimidine nucleosides with carbon tetrabromide followed by an efficient and stereoselective debromination promoted by diethyl phosphite and triethylamine is presented.
Key words： brivudine; gem-dibromoalkenes; debromination
Li Peiyuan , Zhang Jianrui , Guo Shenghai , Zhang Xinying , Fan Xuesen . New Synthesis of Brivudine and Its Analogs[J]. Chinese Journal of Organic Chemistry, 2015 , 35(4) : 910 -916 . DOI: 10.6023/cjoc201410034
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