Chinese Journal of Organic Chemistry >
Combinatorial Synthesis of Flavonoids and 4-Hydroxy-δ-lactones by Plant-Originated Enzymes
Received date: 2014-09-25
Revised date: 2014-12-25
Online published: 2015-01-07
Supported by
Project supported by the Program for New Century Excellent Talents in University (No.NCET-11-0604), the Beijing Natural Science Foundation (No.5132022) and the Independent Subject of Beijing University of Chinese Medicine (No.2014-JYBZZ-XS-091).
4-Coumarate coenzyme A ligase (4CL) and chalcone synthase (CHS), the two pivotal enzymes involved in the biosynthesis of flavonoids were applied to combinatorially synthesize varied unnatural natural products. As result, 25 unnatural natural products including eight flavonoid analogues, 16 4-hydroxy-δ-lactones and one benzalacetone were synthesized by 4CL and CHS. The synthetic methodology would be useful for the construction of library of structurally diverse of small molecules.
Mo Ting , Wang Juan , Gao Bowen , Zhang Le , Liu Xiao , Wang Xiaohui , Tu Pengfei , Shi Shepo . Combinatorial Synthesis of Flavonoids and 4-Hydroxy-δ-lactones by Plant-Originated Enzymes[J]. Chinese Journal of Organic Chemistry, 2015 , 35(5) : 1052 -1059 . DOI: 10.6023/cjoc201409042
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