Chinese Journal of Organic Chemistry >
Synthesis and Antifungal Activity of Novel 3-[(5-Benzylthio- 1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol- (oxazol)-2(3H)-ones
Received date: 2014-10-31
Revised date: 2014-12-14
Online published: 2015-01-07
Supported by
Project supported by the National Natural Science Foundation of China (No.30900959) and Public Project of Zhejiang Province (No.2014C31127).
In order to find novel biologically active pesticide lead compounds, twenty-one novel 3-[(5-benzylthio-1,3,4- oxadiazol-2-yl)methyl]benzo[d]thiazol(oxazol)-2(3H)-ones were synthesized by 2-benzothiazolinone/benzoxazolone as starting materials via substitution, hydrazine, cyclization and the last benzylation reaction. The structures of the title compounds were characterized by 1H NMR, IR, EI-MS and elemental analysis. The preliminary bioassay results indicated that most of them showed moderate inhibition activity against Colletotrichum orbiculare, Botrytis cinerea and Rhizoctonia solani at 50 mg/L, and the inhibition rate of compound 5b against Botrytis cinerea and Rhizoctonia solani reached above 85%.
Ruan Lingli , Fan Renjie , Liu Xinghai , Chen Jie , Weng Jianquan . Synthesis and Antifungal Activity of Novel 3-[(5-Benzylthio- 1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol- (oxazol)-2(3H)-ones[J]. Chinese Journal of Organic Chemistry, 2015 , 35(5) : 1166 -1172 . DOI: 10.6023/cjoc201410041
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