Chinese Journal of Organic Chemistry >
"One-Pot" Synthesis of Ketones from the Reaction of Weinreb Amides and Halides Prompted by Magnesium Powder
Received date: 2014-11-10
Revised date: 2014-12-11
Online published: 2015-01-09
Supported by
Project supported by the National Natural Science Foundation of China (No.21462037).
The “one-pot” reaction of Weinreb amides and halides promoted by magnesium powder was investigated under air atmosphere at room temperature. It was found that the Weinreb amides from monocarboxylic acid can react with halides to give corresponding ketones efficiently. Keto Weinreb amides or diketones can be obtained from the reaction of the Weinreb amides with halides under different reaction conditions. The method has the advantages of simple operation and high yields.
Key words： one-pot; Weinreb amides; keto Weinreb amides; diketones
Wang Fengjiao, Lu Ailing, Huang Danfeng, Su Yingpeng, Xia Xiaowen, Xü Yanli, Wang Ke-Hu, Hu Yulai . "One-Pot" Synthesis of Ketones from the Reaction of Weinreb Amides and Halides Prompted by Magnesium Powder[J]. Chinese Journal of Organic Chemistry, 2015 , 35(5) : 1046 -1051 . DOI: 10.6023/cjoc201411014
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