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Chinese Journal of Organic Chemistry >

2015 , Vol. 35 >Issue 5: 1156 - 1160

DOI: https://doi.org/10.6023/cjoc201411040

Notes

Pt Catalyzed C—H Activation of Purines and Aryl Boric Acids to 8-Aryl Purine Analogues

  • Niu Hongying ,
  • Su Lingyun ,
  • Zhang Qiqi ,
  • Zhang Wanna ,
  • Fu Hongyan ,
  • Li Jianping ,
  • Qu Guirong ,
  • Guo Haiming
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  • a School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003;
    b School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007

Received date: 2014-11-25

  Revised date: 2014-12-29

  Online published: 2015-01-09

Supported by

Project supported by the National Natural Science Foundation of China (Nos.21272059, 21202039, 21472037), the Program for Science & Technology Innovation Talents in Universities of Henan Province (No.13HASTIT013), and the National Training Programs of Innovation for Undergraduates (No.201310467062).

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Abstract

C-8 aryl substituted purine analogues were successfully synthesized by direct C—H activation of purines with aryl boric acids catalyzed by Pd(PPh3)4 in the presence of CuI and piperidine in DMF at 125 ℃ for 24 h, providing a new process for the syn-thesis of 8-aryl purines.

Key words： purine; C—H activation; aryl boric acid; arylation

Cite this article

Niu Hongying , Su Lingyun , Zhang Qiqi , Zhang Wanna , Fu Hongyan , Li Jianping , Qu Guirong , Guo Haiming . Pt Catalyzed C—H Activation of Purines and Aryl Boric Acids to 8-Aryl Purine Analogues[J]. Chinese Journal of Organic Chemistry, 2015 , 35(5) : 1156 -1160 . DOI: 10.6023/cjoc201411040

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