Chinese Journal of Organic Chemistry >
Synthesis and Vasodilatation of Homoisoflavones
Received date: 2014-11-20
Revised date: 2014-12-30
Online published: 2015-01-14
Supported by
Project supported by the Innovation Project on Science and Technology of Shanxi Province (No.2012KPCL03-20).
Homoisoflavones were designed as vasodilative agents on the basis of scaffold hopping. A series of homoisoflavones were synthesized from 2-acetylphenol and aromatic aldehyde via aldol condensation, hydrogenation and cyclization. The structures of title compounds were characterized by 1H NMR, MS and HRMS. The vasodilative effects of synthesized compounds were evaluated by wire myograph on isolated rat mesenteric arterial ring induced contraction with 60 mmol/L KCl. The results suggest that the title compounds are novel vasodilative agents.
Key words： homoisoflavones; synthesis; vasodilatation
Zheng Guoxun , Zhang Zongchang , Kang Borui , Yu Ruihong , Cao Yongxiao , Zhang Sanqi . Synthesis and Vasodilatation of Homoisoflavones[J]. Chinese Journal of Organic Chemistry, 2015 , 35(5) : 1112 -1122 . DOI: 10.6023/cjoc201411033
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