Chinese Journal of Organic Chemistry >
Synthesis of Methylene-Bridged Bis-1,3-dicarbonyl Compounds under Aerobic Condition
Received date: 2014-12-20
Revised date: 2015-02-02
Online published: 2015-02-10
Supported by
Project supported by the National Key Basic Research Program of MOST of China (973 Program, No. 2012CBA01204) and the National Natural Science Foundation of China (No. 21302084).
A simple route for the preparation of methylene-bridged bis-1,3-dicarbonyl compounds was achived through a cleavage of C—N bond of tertiary amines. In this reaction, tetramethylethylenediamine (TMEDA) was used as the methylene source, and cuprous iodide as catalyst under aerobic condition. The substrates bearing different substituents were tolerated well and afforded the corresponding products with moderate to good yields.
Key words： air; tertiary amines; C—N bond cleavage; methylene-bridged compounds
Guo Shengmei , Gong Jiuhan , Lu Lin , Zhu Zheng , Cai Hu . Synthesis of Methylene-Bridged Bis-1,3-dicarbonyl Compounds under Aerobic Condition[J]. Chinese Journal of Organic Chemistry, 2015 , 35(6) : 1348 -1352 . DOI: 10.6023/cjoc201412035
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