Chinese Journal of Organic Chemistry >
Synthesis and Antileishmanial Activity of Pyrimidine Nucleoside- Chalcone Hybrids
Received date: 2015-01-14
Revised date: 2015-02-11
Online published: 2015-02-12
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21172057, 21272058, 21202040), the Program for Science and Technology Innovation Talents in Universities of Henan Province (No. 15HASTIT005), and the Program for Innovative Research Team in Science and Technology in University of Henan Province (No. 15IRTSTHN003).
In this paper, a group of pyrimidine nucleoside-chalcone hybrids were conveniently prepared through condensing 5-formyl pyrimidine nucleosides with (substituted) acetophenones under the promotion of aqueous sodium hydroxide. The hybrid compounds were then evaluated as potential antileishmanial agents and some of them showed promisingly potent activities.
Key words： pyrimidine nucleosides; chalcones; hybrids; antileishmanial activity
Zai Wenjing , Jiang Panpan , Zhang Xinying , Loiseau Philippe M. , Guo Shenghai , Fan Xuesen . Synthesis and Antileishmanial Activity of Pyrimidine Nucleoside- Chalcone Hybrids[J]. Chinese Journal of Organic Chemistry, 2015 , 35(6) : 1335 -1341 . DOI: 10.6023/cjoc201501018
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