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Chinese Journal of Organic Chemistry >

2015 , Vol. 35 >Issue 4: 827 - 834

DOI: https://doi.org/10.6023/cjoc201412045

ARTICLE

Copper Nanoparticles Catalyzed Three-Component Coupling of Alkyne, Dihalomethane and Amine for the Synthesis of Propargylic Amine

  • Zeng Suwei ,
  • Xu Sen ,
  • Wang Yong ,
  • Yu Min ,
  • Zhu Li ,
  • Yao Xiaoquan
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  • a Department of Applied Chemistry, Nanjing University of Aeronautics and Astronautics, Nanjing 210016;
    b School of Pharmacy, Nanjing Medical University, Nanjing 210029

Received date: 2014-12-27

  Revised date: 2015-03-12

  Online published: 2015-03-17

Supported by

Project supported by the National Natural Science Foundation of China (No. 21172107).

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Abstract

A copper nanoparticles-catalyzed three-component coupling reaction of alkyne, dihalomethane, and amine (AHA coupling) was reported for the synthesis of propargylic amine. The catalytic AHA coupling reaction was carried out under mild conditions with dihalomethane as substrate and solvent, and good to excellent yields were also achieved. Furthermore, the nanoparticle catalyst could be recovered and reused effectively, and no obvious reduction on catalytic activity was observed for five recycles.

Key words： copper nanoparticles; AHA coupling reaction; propargylic amines; catalyst recycling

Cite this article

Zeng Suwei , Xu Sen , Wang Yong , Yu Min , Zhu Li , Yao Xiaoquan . Copper Nanoparticles Catalyzed Three-Component Coupling of Alkyne, Dihalomethane and Amine for the Synthesis of Propargylic Amine[J]. Chinese Journal of Organic Chemistry, 2015 , 35(4) : 827 -834 . DOI: 10.6023/cjoc201412045

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