Chinese Journal of Organic Chemistry >
Gold-Catalyzed Tandem Reactions of 2-Alkynyl Arylazides and Carboxylic Acids for the Synthesis of 1H-Indol-3-yl Esters
Received date: 2015-01-15
Revised date: 2015-03-17
Online published: 2015-03-24
Supported by
Project supported by the Young National Natural Science Foundation of China (No. 21302096), the Young Natural Science Foundation of Jiangsu Province (No. BK20130962), the Project Fund from the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and the National Natural Science Foundation of China (No. 21372117).
1H-Indol-3-yl acetates are very important indole derivatives, which can be found in many bioactive compounds and natural products. In this work, 1H-indol-3-yl acetates were efficiently prepared via α-imino gold carbenes generated by gold-catalyzed reactions of 2-alkynyl arylazides. A very simple and general method for the synthesis of 1H-indol-3-yl acetates was provided after examining the substrates scope.
Zhang Xiaoxiang , Sun Xiaoping , Zhang Haifei , Cui Xingli , Ma Mengtao . Gold-Catalyzed Tandem Reactions of 2-Alkynyl Arylazides and Carboxylic Acids for the Synthesis of 1H-Indol-3-yl Esters[J]. Chinese Journal of Organic Chemistry, 2015 , 35(7) : 1469 -1474 . DOI: 10.6023/cjoc201501020
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