Chinese Journal of Organic Chemistry >
A Facile and New Synthetic Method of Polysubstituted Furans
Received date: 2015-03-16
Revised date: 2015-03-30
Online published: 2015-04-10
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21272119, 21121002), and the Natural Science Foundation of Hubei Province (No. 2007ABA375).
With the treatment of tributylphosphine and base, alkynoates, aromatic aldehydes and acyl chlorides readily undergo a four-component cascade annulation reaction, giving tri-or tetra-substituted furans in moderate yields. The reaction presumably proceeds through an intramolecular Wittig reaction step of the in situ generated phosphorus ylide intermediate. The annulation reaction features mild reaction conditions and broad substrate scope, and accordingly constitutes a facile and new synthetic method of polysubstituted furans.
Key words： furans; synthesis; phosphines; multicomponent reactions; Wittig reaction
Zou Wen , He Zheng-Rong , He Zhengjie . A Facile and New Synthetic Method of Polysubstituted Furans[J]. Chinese Journal of Organic Chemistry, 2015 , 35(8) : 1739 -1745 . DOI: 10.6023/cjoc201503022
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