Chinese Journal of Organic Chemistry >
Research Progress in Synthesis of Renieramycin-Type Alkaloids
Received date: 2015-04-01
Revised date: 2015-04-22
Online published: 2015-05-06
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21172153, 21321061), the National Basic Research Program of China (973 Program, No. 2010CB833200).
Marine tetrahydroisoquinoline alkaloids have attracted much attention in the fields of chemistry, biology and medicine over the past forty years because of their remarkable antitumor and antimicrobial activities. Among them, renieramycins is a big group, which consists of renieramycins A~Y, jorunnamycins A~C and jorumycin. A number of renieramycins and their analogues showed nanomolar inhibitory effects in a panel of human tumor cell lines. Therefore, along with other tetrahydroisoquinoline antitumor antibiotics, renieramycins are one of hotspots in the synthetic study of natural products. Progresses on the synthesis of renieramycin-type alkaloids are reviewed in terms of the key strategies employed.
Song Yuting , Hu Lingling , Chen Ruijiao , Chen Xiaochuan . Research Progress in Synthesis of Renieramycin-Type Alkaloids[J]. Chinese Journal of Organic Chemistry, 2015 , 35(8) : 1627 -1640 . DOI: 10.6023/cjoc201504003
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