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Chinese Journal of Organic Chemistry >

2015 , Vol. 35 >Issue 9: 1999 - 2003

DOI: https://doi.org/10.6023/cjoc201503026

Notes

Improvement of the Synthesis of Isothiocyanates

  • Li Zhengyi ,
  • Shi Song ,
  • Zhuang Yue ,
  • Zheng Chongqian ,
  • Zhang Jinlong ,
  • Sun Xiaoqiang
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  • Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164

Received date: 2015-03-18

  Revised date: 2015-04-16

  Online published: 2015-05-14

Supported by

Project supported by the National Natural Science Foundation of China (No. 21002009), the Major Program for the Natural Science Research of Jiangsu Colleges and Universities (Nos. 12KJA150002, 14KJA150002), the Scientific and Technological Project of Jiangsu Province (BY2014037-01), and the Qing Lan Project of Jiangsu Province.

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Abstract

Isothiocyanates were prepared from the reactions of phenyl chlorothionoformate and various primary amines vis one-step or two-step process without additional base. The one-step process is good at highly active amines, while two-step approach is suitable for all kinds of amines. This method has many merits such as environment-friendly, easily available raw materials, low toxicity and convenient operation, which has a good application prospect in industry.

Key words： isothiocyanate; phenyl chlorothionoformate; primary amine; synthesis

Cite this article

Li Zhengyi , Shi Song , Zhuang Yue , Zheng Chongqian , Zhang Jinlong , Sun Xiaoqiang . Improvement of the Synthesis of Isothiocyanates[J]. Chinese Journal of Organic Chemistry, 2015 , 35(9) : 1999 -2003 . DOI: 10.6023/cjoc201503026

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