Chinese Journal of Organic Chemistry >
Copper-Catalyzed Oxidative Amidation of Aryl Ketone and ItsDerivatives to Form α-Keto Amides
Received date: 2015-02-07
Revised date: 2015-05-12
Online published: 2015-05-26
Supported by
Project supported by the National Key Basic Research Program of Ministry of Science and Technology of China (No. 2012CBA01204) and the National Natural Science Foundation of China (No. 21302084).
The oxidative amidation between aryl ketone and amine to form keto amide in water was studied. A variety of amides co-catalyzed by copper and iodine were efficiently synthesized using TBHP as an oxidant under room temperature. On the other hand, a copper-catalyzed C—C bond cleavage of β-keto ester and its derivatives to prepare α-keto amides under O2 atmosphere was also studied.
Key words： H2O; O2; aryl ketone; β-keto esters; α-keto amides
Gong Jiuhan , Zhu Zheng , Lu Lin , Guo Shengmei , Cai Hu . Copper-Catalyzed Oxidative Amidation of Aryl Ketone and ItsDerivatives to Form α-Keto Amides[J]. Chinese Journal of Organic Chemistry, 2015 , 35(9) : 1917 -1922 . DOI: 10.6023/cjoc201502010
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