Chinese Journal of Organic Chemistry >
Secondary Metabolites of a Bruguiera sexangula var. Rhynchopetala-Derived Fungus Phomopsis longicolla HL-2232
Received date: 2015-05-27
Revised date: 2015-06-15
Online published: 2015-06-24
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21462015,21362009, 31360069), the Natural Science Foundation of Hainan Province (Nos. 20152037, 20152034), and the Youth Foundation of Hainan Normal University (No. QN1434).
Under the guidance of bioassay, five alkaloids, one chromone and four steroids were isolated from the Phomopsis longicolla HL-2232, a fungus isolated from a mangrove Bruguiera sexangula var. Rhynchopetala. Their structures were identified as 6-aminopurine-9-carboxylic acid methyl ester (1), adenine riboside (2), uridine (3), N,N'-diphenyl urea (4), (2S,2'R,3R,4E,8E,3'E)-2-(2'-hydroxy-3'-octadecenoylamino)-9-methyl-4,8-octadecadiene-l,3-diol (5), 2-(2'S-hydroxypropyl)-5-methyl-7-hydroxychromone (6), fortisterol (7), (22E)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (8), cerevisterol (9) and β-sitosteryl linoleate (10). Among them, compound 1 was a new compound. Compound 5 was a new natural product, and its 13C NMR spectroscopic data has not reported until now. Compounds 1～3 showed inhibitory activities against B16F10, A549, HL-60 and MCF-7. Compounds 1 and 3 exhibited the higher inhibitory activities against MCF-7 and A549 than positive control cisplatin with IC50 values of 14.9 and 8.6 μmol·L-1, respectively.
Song Xinming , Zhou Xueming , Li Xiaobao , Zheng Caijuan , Huang Guolei , Yu Zhangxin , Song Xiaoping , Chen Guangying . Secondary Metabolites of a Bruguiera sexangula var. Rhynchopetala-Derived Fungus Phomopsis longicolla HL-2232[J]. Chinese Journal of Organic Chemistry, 2015 , 35(10) : 2102 -2107 . DOI: 10.6023/cjoc201505044
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