Chinese Journal of Organic Chemistry >
Synthesis and Biological Activities of Novel Substituted Pyrazole Oximes Containing Substituted Pyridine Group
Received date: 2015-06-03
Revised date: 2015-06-30
Online published: 2015-07-10
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), and the Science and Technology Project Fund of Nantong City (No. AS2013002).
In order to explore novel potent pesticide from pyrazole oxime derivatives, a series of new pyrazole oxime ester compounds bearing substituted pyridine moiety were synthesized by the introduction of pyridyl backbone into the molecules of pyrazole oxime. Their structures were confirmed by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay results showed that some of the title compounds displayed certain insecticidal and acaricidal activities. For example, compound 5i exhibited insecticidal activity against Aphis craccivora with 90% mortality at the concentration of 400 μg/mL.
Key words： substituted pyridine; pyrazole oxime; synthesis; bioactivity
Dai Hong , Zhuang Huiyang , Shi Lei , Li Gang , Zhang Haijun , Fang Yuan , Dai Baojiang . Synthesis and Biological Activities of Novel Substituted Pyrazole Oximes Containing Substituted Pyridine Group[J]. Chinese Journal of Organic Chemistry, 2015 , 35(11) : 2399 -2404 . DOI: 10.6023/cjoc201506004
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