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Chinese Journal of Organic Chemistry >

2016 , Vol. 36 >Issue 1: 218 - 221

DOI: https://doi.org/10.6023/cjoc201505014

Notes

Efficient Synthesis of Liraglutide by Using Oxyma as Coupling Reagent

  • Wang Fengliang ,
  • Xu Ling ,
  • Chu Guochao ,
  • Shi Jing ,
  • Guo Qingxiang
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  • Department of Chemistry, University of Science and Technology of China, Hefei 230026

Received date: 2015-05-08

  Revised date: 2015-08-03

  Online published: 2015-09-06

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21272223, 21572214).

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Abstract

As a newly efficient reagent, Oxyma [ethyl 2-cyano-2-(hydroxyimino)acetate] has a lower rate of racemization and relative higher coupling efficiency as compared with HOBt, HOAt, etc. In this work, as an important polypeptide drug for the treatment of diabetes, liraglutide was firstly chemically synthesized with high efficiency by solid chemical synthesis using Oxyma as coupling reagent. The strategy presented here provides an efficient strategy for the chemical synthesis of liraglutide with enlarged scales.

Key words： oxyma; liraglutide; polypeptide drug; solid poly-peptide synthesis

Cite this article

Wang Fengliang , Xu Ling , Chu Guochao , Shi Jing , Guo Qingxiang . Efficient Synthesis of Liraglutide by Using Oxyma as Coupling Reagent[J]. Chinese Journal of Organic Chemistry, 2016 , 36(1) : 218 -221 . DOI: 10.6023/cjoc201505014

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