Chinese Journal of Organic Chemistry >
Synthesis and Bioactivities of Novel Pyrazole Oximes Containing Substituted Thiadiazole Moiety
Received date: 2015-08-18
Revised date: 2015-09-11
Online published: 2015-09-17
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), the Open Project Fund of State Key Laboratory of Elemento-organic Chemistry (No. 201412), the Science and Technology Innovation Foundation for the College Students of Jiangsu Province and the Science and Technology Project Fund of Nantong City (Nos. AS2013004, AS2014011).
In order to find novel potent pesticide from pyrazole oxime derivatives, a series of new pyrazole oximes carrying substituted thiadiazole moiety were prepared by the introduction of the key thiadiazole backbone into the molecules of pyrazole oximes. The structures of the title compounds were characterized by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay data displayed that some of the title compounds showed good insecticidal activities against Aphis craccivora and Nilaparvata lugens. In addition, some target compounds also exhibited certain larvicidal activity against Oriental armyworm.
Key words： substituted thiadiazole; pyrazole oxime; synthesis; biological activity
Dai Hong , Huang Juhua , Jin Zhichao , Cheng Xiaoyan , Huang Kaiwei , Ling Yong , Wang Qingmin , Shi Yujun . Synthesis and Bioactivities of Novel Pyrazole Oximes Containing Substituted Thiadiazole Moiety[J]. Chinese Journal of Organic Chemistry, 2015 , 35(12) : 2617 -2623 . DOI: 10.6023/cjoc201508018
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