Chinese Journal of Organic Chemistry >
Ultrasound Promoted Synthesis of Novel Substituted Spirooxindole Compounds Containing Thiochroman Moiety with Antifungal Activity
Received date: 2015-08-06
Revised date: 2015-09-23
Online published: 2015-09-25
Supported by
Project supported by the Open Project Program of Key Laboratory of Pharmaceutical Quality Control of Hebei Province, the National Major Scientific and Technological Special Project for ‘Significant New Drugs Development’ (No. 2012ZX09103-101-057).
A rapid and efficient ultrasound-promoted one-pot synthesis of 2'-amino-2-oxo-5'H-spiro[indoline-3,4'-thiochromeno[4,3-b]pyran]-3'-carbonitrile compounds by one-pot three-component reaction had been developed. Structures of all products were characterized by 1H NMR, 13C NMR and HRMS. The effect of ultrasound on yield and reaction time had been studied to understand the role of ultrasound in the reaction. The antifungal activity was determined by micro dilution method. Compound 4f exhibited inhibitory activity to Cryptococcus neoformans, Epidermophyton floccosum and Mucor racemosus better than the positive control drug fluconazole.
Zhou Guan , Liang Guochao , Zhong Yifan , Han Xiaoyan , Chen Guofeng , Song Yali . Ultrasound Promoted Synthesis of Novel Substituted Spirooxindole Compounds Containing Thiochroman Moiety with Antifungal Activity[J]. Chinese Journal of Organic Chemistry, 2016 , 36(1) : 143 -150 . DOI: 10.6023/cjoc201508007
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