Chinese Journal of Organic Chemistry >
Synthesis and Bioactivity of Novel 1-Methyl-3-trifluoromethyl- 5-subsituent-1H-pyrazole-4-carbaldehyde- O-(4-trifluoromethylbenzoyl)oximes
Received date: 2015-08-29
Revised date: 2015-10-08
Online published: 2015-10-23
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), the Natural Science Foundation of Jiangsu Province (No. BK20140425), and the Science and Technology Project Fund of Nantong City (Nos. AS2013004, CP12013002, AS2014011).
In order to find novel pesticide from pyrazole compounds, a series of new pyrazole derivatives carrying trifluoromethyl benzoyl oxime ester moiety were prepared. The structures of all the title compounds were determined by 1H NMR, 13C NMR, MS and elemental analysis. Preliminary bioassay displayed that most of the target compounds showed certain insecticidal activities at the concentration of 500 μg/mL. When the concentration was reduced to 200 μg/mL, compounds 5b, 5c, 5d, 5i, 5l and 5n were still active against Aphis craccivora with inhibitory values of 90%, 90%, 80%, 80%, 80% and 80%, respectively.
Key words： trifluoromethyl benzoyl; pyrazole; synthesis; biological activity
Dai Hong , Li Hong , Jin Zhichao , Liu Wenyong , Xiao Yao , He Haibing , Wang Qingmin , Shi Yujun . Synthesis and Bioactivity of Novel 1-Methyl-3-trifluoromethyl- 5-subsituent-1H-pyrazole-4-carbaldehyde- O-(4-trifluoromethylbenzoyl)oximes[J]. Chinese Journal of Organic Chemistry, 2016 , 36(1) : 185 -190 . DOI: 10.6023/cjoc201508028
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