Chinese Journal of Organic Chemistry >
Synthesis, Crystal Structure and Biological Activity of Novel 1-(Pyridin-2-yl)-2-aryloxy-2-(1H-1,2,4-triazol-1-yl)ethanones
Received date: 2015-09-08
Revised date: 2015-09-30
Online published: 2015-11-03
Supported by
Project supported by the National Natural Science Foundation of China (No. 20772068), the Open Project Fund of State Key Laboratory of Elemento-organic Chemistry (No. 201412), and the Science and Technology Project Fund of Nantong City (Nos. CP12013002, AS2014011)
In order to find novel triazole lead compounds, a series of new triazole derivatives containing pyridine moiety were synthesized by the introduction of the important pyridyl backbone into the molecules of triazoles. They were structurally confirmed by 1H NMR, 13C NMR, IR, MS and elemental analysis. Additionally, compound 4k was structurally characterized through X-ray single crystal diffraction method. Preliminary bioassay data showed that some of the title compounds displayed moderate fungicidal and plant growth regulatory activities.
Key words： triazole; pyridine; synthesis; bioactivity
Dai Hong , Liu Jianbing , Tao Weifeng , Miao Wenke , Fang Jianxin , Wang Qingmin . Synthesis, Crystal Structure and Biological Activity of Novel 1-(Pyridin-2-yl)-2-aryloxy-2-(1H-1,2,4-triazol-1-yl)ethanones[J]. Chinese Journal of Organic Chemistry, 2016 , 36(2) : 393 -398 . DOI: 10.6023/cjoc201509011
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