Chinese Journal of Organic Chemistry >
Synthesis and Bioactivity of Novel Pyridine Phenyl Ethers Bearing N-heterocycles
Received date: 2015-10-19
Revised date: 2015-11-05
Online published: 2015-11-20
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), and the Science and Technology Project Fund of Nantong City (Nos. AS2013002, MS22015020, AS2014011).
In order to find novel pyridine phenyl ether lead compounds, a series of novel pyridine phenyl ether derivatives containing N-heterocycles were prepared by the strategy of active substructure combination. Their structures were determined by 1H NMR, 13C NMR, IR and elemental analysis. Preliminary bioassay data displayed that some of the designed compounds exhibited good insecticidal activity. Additionally, some target compounds showed significant anti-tumor activities.
Key words： N-heterocycle; pyridine phenyl ether; synthesis; bioactivity
Dai Hong , Chen Jia , Cao Xiongfei , Miao Wenke , Shi Yujun , Fang Jianxin , Ye Linyu , Zhong Sulin . Synthesis and Bioactivity of Novel Pyridine Phenyl Ethers Bearing N-heterocycles[J]. Chinese Journal of Organic Chemistry, 2016 , 36(2) : 377 -383 . DOI: 10.6023/cjoc201510020
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