Chinese Journal of Organic Chemistry >
Design and Synthesis of Oleanolic Acid Rings A and C Lactone Derivatives
Received date: 2015-09-01
Revised date: 2015-11-27
Online published: 2015-12-07
Supported by
Project supported by the Open-Fund Program of the State Key Laboratory of Natural and Biomimetic Drugs (No. K20150214), the Scientific Research Foundation of Kunming University of Science and Technology (No. KKSY201560002).
Oleanolic acid (OA), a naturally occurring triterpene, was found to have a variety of biological and pharmacological properties. To expand its structural diversity, a series of oleanolic acid derivatives, including ring A and/or ring C expansion, were performed via Baeyer-Villiger reaction using m-CPBA and urea-hydrogen peroxide. The structures of all products were characterized by 1H NMR, 13C NMR and HRMS.
Key words： oleanolic acid; Baeyer-Villiger reaction; lactone
Yu Fei , Zheng Yongxiang , Peng Yiyun , Zhou Demin , Xiao Sulong . Design and Synthesis of Oleanolic Acid Rings A and C Lactone Derivatives[J]. Chinese Journal of Organic Chemistry, 2016 , 36(3) : 512 -519 . DOI: 10.6023/cjoc204509001
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