Chinese Journal of Organic Chemistry >
Synthesis and Antibacterial Activities of Novel Quinazoline-2,4-dione Derivatives Containing the 1,2,4-Triazole Schiff-Base Unit
Received date: 2015-10-09
Revised date: 2015-11-05
Online published: 2015-12-10
Supported by
Project supported by the National Natural Science Foundation of China (No. 21362003).
Eighteen novel quinazoline-2,4-dione derivatives containing the 1,2,4-triazole Schiff-base unit were designed and synthesized, based on the connection method of active fragments. Their structures were characterized by 1H NMR, 13C NMR, MS, IR and elemental analysis. The preliminary antibacterial test indicated that all the target compounds possessed an excellent inhibition activity (≥ 93%) against Xanthomonas oryzae pv. oryzae (Xoo) at the concentration of 200 μg/mL, which was obviously better than those of control agents thiodiazole-copper and bismerthiazol. Compounds 7a, 7c~7g and 7j~7l still displayed 100% inhibition rate against Xoo even at the concentration of 100 μg/mL. Moreover, all the target compounds exhibited a certain inhibition activity against Xanthomonas axonopodis pv. citri, but no inhibition activity against Ralstonia solanacearum.
Pan Dingwu, Du Huan, Lü Xinyang, Bao Xiaoping . Synthesis and Antibacterial Activities of Novel Quinazoline-2,4-dione Derivatives Containing the 1,2,4-Triazole Schiff-Base Unit[J]. Chinese Journal of Organic Chemistry, 2016 , 36(4) : 818 -825 . DOI: 10.6023/cjoc201510005
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